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  • by Nicola Boulton September 01, 2022 5 min read

    CBD for PMS; Could It Be a Woman's New Best Friend?

    Cannabidiol (CBD), a non-intoxicating cannabis compound, promotes general health and wellness. Premenstrual Syndrome (PMS) results from neurochemical and hormone level that shifts approximately 5-11 days before a woman gets her periods. Cannabidiol is reported to help women with this problem. Learn how it functions here.

    Cannabidiol (CBD), a non-intoxicating cannabinoid compound, is used to address multiple health issues. Premenstrual syndrome (PMS) cause bloating and mood swings, the adverse symptoms which are disruptive and vary with people. PMS is poorly understood and under-researched like most disorders affecting female reproductive wellbeing. Although some women get relief from traditional NSAIDs painkillers (ibuprofen and aspirin), exercise, and diet, most suffer silently. Researchers have established cannabidiol's potential benefits as an alternative and natural treatment for certain ailments and health conditions. It contains mood-improving impacts and pain-relieving qualities, which might impact PMS symptoms positively. However, keep reading to acquire concrete information about cannabidiol for PMS.

    Cannabidiol Versus Common Pharmaceuticals in Treating PMS

    The strain and volume of premenstrual syndrome symptoms troubles people who attempt to address this condition. Although healthy lifestyle adjustments are beneficial, drugs are important. The most acclaimed pharmaceutical treatments relieve the person but experience certain negative side effects that trigger health problems altogether. Cannabidiol would help the person since it has minimal mild side effects. Although antidepressants address mood changes, their side effects include nausea, insomnia, headaches, nervousness, and drowsiness. Cannabidiol does not generate any related side effects but reduces depression and anxiety. Non-steroidal anti-inflammatory drugs (NSAIDs) (celecoxib, naproxen, ibuprofen, and aspirin) treat inflammation and pain, but consumers experience stomach pain, ulcers, dizziness, spiked blood pressure, and kidney and liver problems. CBD lowers inflammation and pain without causing such side effects. Diuretics (Aldactone) treat bloating, but users experience stomach pain, headaches, nausea, and skin rash. Cannabidiol has anti-inflammatory impacts on the human digestive system, alleviating bloating problems without causing adverse side effects. Hormonal contraceptives (hormonal injections, contraceptive patches, IUDs, and birth control pills) address combined symptoms but trigger migraines, headaches, anxiety, weight gain, blood clots, fatigue, ovarian cysts, and mood changes. However, cannabidiol generates various emotional and physical benefits causing such side effects. Learn more about how does cbg help with digestion?

    Cannabidiol for Various PMS Symptoms

    According to Tang et al. (2021), cannabidiol's anti-inflammatory impacts on the body's CB2 endocannabinoid neurotransmitters could decrease severe pain and weight-and mood-associated with PMS symptoms. Cannabidiol interacts with CB2 and CB1 endocannabinoid receptors in the human central and peripheral nervous system. The former controls inflammation and pain by moderating body immune responses. Through CB2 and CBD interaction, inflammation is stopped before occurring. Most women depend on anti-inflammatory medications such as ibuprofen and aspirin for PMS help. De Jong et al. (2021) established a causal link between premenstrual symptoms and inflammation. The research above determined the inflammation levels in mid-aged women who almost got their period and the negative PMS effects such as weight gain, mood changes, and back and breast pain increased with internal inflammation. Premenstrual headaches and PMS symptoms were not associated with increased inflammation levels. When CBD impacts CB2 receptors indirectly, various anti-inflammatory reactions are stimulated in your body. Therefore, consumers are relieved from various adverse PMS symptoms when cannabidiol is utilized to control inflammation through CB2 activation. Learn more about what is cbd pain freeze?

    Cannabidiol for PMS Pain Relief

    Individuals have used cannabis products to relieve PMS and menstrual pain for centuries. The cannabis plant contains over 113 cannabinoid chemical compounds. Kalaba & Ware (2021) revealed that cannabidiol significantly relieves users from physical symptoms such as soreness and headaches that most women with premenstrual syndrome experience. Cannabidiol interacts with human glycine receptors, essential functions in perceiving pain. According to McDonagh et al. (2021), CBD is an essential categorization of beneficial compounds for treating chronic pain. The cannabidiol's interrelation with glycerine neurotransmitters differs from how it activates CB2 receptors. This implies cannabidiol could deliver relief from inflammation and PMS pain by simultaneously impacting two unique inflammation and pain mechanisms in the human body. Tetrahydrocannabinol (THC), a cannabis psychoactive compound, is beneficial, especially when dealing with PMS pain associated with cramping. According to Asada et al. (2021), menstruation cramps are caused by contracting muscles. The study above suggested that combining cannabidiol and tetrahydrocannabinol for muscle spasticity relaxes muscles and relieves pain. Individuals residing in regions where recreational and medical marijuana are authorized can consider taking whole-plant spectrum cannabidiol, which constitutes tetrahydrocannabinol, to control PMS cramps' frequency and pain. Research whether your State legalizes cannabis products to avoid breaching State laws. Sinclair et al. (2022) noted that tetrahydrocannabinol controls pain, although cannabidiol relieves pain experienced by women with premenstrual syndrome.

    Cannabidiol for Mood

    Rapid mood fluctuations are prevalent PMS symptoms. Most women report irritability before their period, depression, and anxiety bouts. Cavalli & Cservenka (2021) stated that cannabidiol is essential in moderating mood in individuals with depression and anxiety. Also, the compound inhibits anandamide reabsorption, implying it elevates the anandamide amount in your brain. Anandamide, a bliss molecule, stimulates joy and regulates motivation, positivity, and happy feelings. Therefore, cannabidiol's impacts on anandamide amounts in the brain remedies irritability and melancholy feelings experienced during PMS. Adenosine, a body chemical, can support mood regulation by impacting particular neurotransmitter pathways. Jenner et al. (2020) showed that adenosine has a significant role in cognitive processes associated with depression and anxiety. A2A adenosine receptor causes dopamine production, which is paramount in fighting depression. Since cannabidiol increases adenosine availability, A2A is more stimulated, causing greater dopamine synthesis and eventually reduced anxiety, elevated clarity, and mood. Mood disturbances, inflammation, and untreated pain might harden daily functioning for most people. Cannabidiol uses several methods, including oral, sublingual, topical, and vaping. Vaping provides immediate results, followed by sublingual, topical, and oral. Choose your appropriate method to enjoy maximum cannabidiol benefits.


    Premenstrual syndrome strains and intensities make it hard for people to address the issues. Changing lifestyle is beneficial, although using certain curative drugs is paramount. Unfortunately, drugs like antidepressants are beneficial but have adverse side effects, including nausea, insomnia, headaches, nervousness, and drowsiness. Therefore, consider cannabidiol since it alleviates pain and inflammation without causing unpleasant effects. Also, its anti-inflammatory impacts on your CB2 endocannabinoid neurotransmitters could decrease severe pain-and weight-and mood-associated with PMS symptoms. CBD products are beneficial and have minimal side effects, although they can interact with certain prescription medications. Therefore, consult your medical practitioner before incorporating these supplements into your routine for a healthy life.


    Asada, C., Tsutsumi, K., Tamura, Y., Hara, N., Omori, W., Otsuka, Y., & Sato, K. (2021). Electrical Muscle Stimulation To Develop And Implement Menstrual Simulator System. Journal Of Robotics And Mechatronics, 33(5), 1051-1062.

    Cavalli, J. M., & Cservenka, A. (2021). Emotion Dysregulation Moderates The Association Between Stress And Problematic Cannabis Use. Frontiers In Psychiatry, 11, 597789.

    De Jong, W. H., Panagiotakos, D., Proykova, A., Samaras, T., Clemens, M. W., De Jong, D., ... & Zacharov, S. (2021). Final Opinion On The Safety Of Breast Implants About Anaplastic Large Cell Lymphoma: Report Of The Scientific Committee On Health, Emerging And Environmental Risks (SCHEER). Regulatory Toxicology And Pharmacology, 125, 104982.

    Jenner, Mori, & Kanda (2020). Can Adenosine A2A Receptor Antagonists Be Used To Treat Cognitive Impairment, Depression, Or Excessive Sleepiness In Parkinson's Disease? Parkinsonism & Related Disorders, 80, S28-S36.

    Kalaba, M., & Ware, M. A. (2021). Cannabinoid Profiles In Medical Cannabis Users: Effects Of Age, Gender, Symptoms, And Duration Of Use. Cannabis And Cannabinoid Research.

    Mcdonagh, Wagner, Ahmed, Morasco, Kansagara, & Chou (2021). Living Systematic Review On Cannabis And Other Plant-Based Treatments For Chronic Pain.

    Sinclair, J., Armour, S., Akowuah, J. A., Proudfoot, A., & Armour, M. (2022). "Should I Inhale?"—Perceptions, Barriers, And Drivers For Medicinal Cannabis Use Amongst Australian Women With Primary Dysmenorrhoea: A Qualitative Study. International Journal Of Environmental Research And Public Health, 19(3), 1536.

    Tang, Wolk, Britch, Craft, & Kendall (2021). Anti-Inflammatory And Antinociceptive Effects Of The Selective Cannabinoid CB2 Receptor Agonist ABK5. Journal Of Pharmacological Sciences, 145(4), 319-326.

    Nicola Boulton
    Nicola Boulton

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