Your Cart is Empty

  • Add description, images, menus and links to your mega menu

  • A column with no settings can be used as a spacer

  • Link to your collections, sales and even external links

  • Add up to five columns

  • by Nicola Boulton September 28, 2022 5 min read

    How Long Does It Take for CBD Cream to Work on Muscle Pain?

    CBD cream can help calm and relax your muscle pains after a tiresome day. However, the question is the time it will take to feel relieving effects. Continue reading the blog as it explains the onset time CBD cream takes to manifest calming effects for muscle pain by outlining; what CBD cream is, how CBD cream interacts with the skin for muscle pain, and the factors that determine how long it takes to work on muscle pain.

    CBD merchandise is the primary trending herbal remedy in the current market. One available product is CBD cream, which relieves body pain, such as joint discomfort. CBD creams are simple and convenient since you need to apply them to the skin using a spatula, fingers, or patches. Apart from nourishing and hydrating the skin, the skincare CBD product can be used to relieve chronic muscle inflammation. CBD is absorbed into the inner skin layers, where it interacts with pain receptors to induce muscle relaxation. However, the main question customers in the skincare industry ask is how long it will take for the products to work.

    What Is CBD Cream?

    Eskander et al. (2020) stated that CBD cream is a skincare product infused with CBD oil, applied to harness the power of CBD. Cannabidiol (CBD) is an active, healthy compound extracted from the leaves and flowers of the cannabis plant, especially the legal hemp plant. Like other CBD products such as gummies, the cream form does not induce a feeling of highness and confusion, primarily associated with tetrahydrocannabinol (THC). However, the Food and Drug Administration (FDA) has not regulated the manufacturing and retailing of hemp products. Therefore, you can easily find CBD cream contaminated with THC molecules above the recommended mark (less than 0.3%). Additionally, there are three different types of CBD cream for pain, namely:

    CBD Cream Isolate

    CBD isolate contains 99% of CBD compound with no contamination of other plant psychochemical.

    Broad-spectrum CBD Cream

    Broad-spectrum CBD contains almost all cannabinoids, such as terpenes, except THC.

    Full-spectrum CBD Cream

    Full-spectrum CBD contains all traces of other cannabinoids, including a small amount of THC (less than 0.3%)

    How Does CBD Cream Interact with the Skin for Muscle Pain?

    McPartland et al. (2015) explained that CBD cream penetrates through the deeper layers of the skin to interact with CB2 receptors. The receptors are components of the endocannabinoid system (ECS) mandated to control body balance by tackling anxiety, stress, sleep issues, appetite, and body pain. CBD increases the release of anandamide, connecting with CB2 receptors to act as a healing agent to help repair damaged muscle tissue hence combating inflammation causing pain. Also, CBD cream may penetrate the circulatory system, which interacts with CB1 cannabinoid receptors that release 2-AG body cannabinoids. This blocks the pain signals through electric nerve impulses, making you experience muscle relaxation and mental calmness.

    Factors That Determine How Long CBD Cream Takes to Work on Muscle Pain

    Chemical trials on people with different body chemistry showed that CBD cream's effectiveness on muscle and mind relaxation could take 30 to 90 minutes. The range is caused by factors such as metabolism and lifestyle, body weight, frequent use, method of application, and CBD cream potency and dosage.

    Metabolism and Lifestyle

    A person's metabolic rate can interfere with the effectiveness of CBD. According to  Giacoppo et al. (2015), metabolism determines the time your body receptors take to synthesize and interact with CBD compounds, thus the onset time to feel relief from muscle pain. Therefore, people with high metabolic processes will feel calm faster than ones with low metabolism. You can increase your body's metabolic process by living an active lifestyle, such as practicing physical exercises, meditation, and eating energetic foods.

    Body Weight

    People with a high concentration of body fat require a high CBD dosage to feel its effects. Body weight can also affect the period taken for CBD cream to work. CBD compounds are fat soluble. Therefore, they can quickly dissolve into fatty cells, delaying the interaction period with skin receptors. The larger the body weight, the longer the time required to feel the effects of CBD cream.

    Frequency of Use

    The more you apply CBD cream, the less time it will take to feel its benefits. According to Antonelli & Donelli (2020), newbies to CBD skincare can take up to 90 minutes to feel the calming effects of CBD compared to the 30 minutes regular users take.

    Method of Application

    There are two ways to apply CBD cream for muscle relief: rubbing directly to the affected area and transdermal. Each method of intake has a different onset period in tackling muscle pain.

    Rubbing Directly to the Skin

     This is the best method to tackle muscle and joint pain. Deeply and gently rub CBD cream on the affected muscle, and in less than 60 minutes, the cannabinoid will interact with pain receptors to relieve the condition.


    The transdermal application of CBD cream is suitable for long-term purposes. Patches are applied with CBD cream and attached to the injured muscle or joints. They have permeation enhancers that allow fast penetration of CBD compounds into the skin, and within less than 30 minutes, the analgesic effects of the cannabinoid will kick in.

    CBD Cream Potency and Dosage

    Potency is the given power of a supplement to deliver an effective result. CBD products' potency plays a massive role in determining their effectiveness; it is possible not to feel the effects of low CBD cream potency since the cannabinoid present is not enough to relieve muscle pains. High potent CBD will deliver results faster and more effectively due to its power to interact quickly with body receptors. Additionally, a CBD cream dosage of 10 mg cannot have the same onset time as 50 mg in tackling pain. The high the dosage, the less time it will take for effects to kick in.


    Applying CBD cream is the best way to handle muscle fatigue and pains after a long active day. Cannabidiol cream interacts with CB1 and CB2 receptors to block the signaling of muscle pain terminals in the central nervous system. This will make you feel relaxed and calm. It will take approximately 30 to 90 minutes to feel the calming effects of CBD. However, this depends on the method of use, CBD cream potency, the dosage applied, body chemistry, and frequency of use.


    Antonelli, M., & Donelli, D. (2020). Efficacy, safety, and tolerability of aroma massage with lavender essential oil: An overview. International journal of therapeutic massage & bodywork, 13(1), 32.

    Eskander, J. P., Spall, J., Spall, A., Shah, R. V., & Kaye, A. D. (2020). Cannabidiol (CBD) as a treatment of acute and chronic back pain: A case series and literature review. J Opioid Manag, 16(3), 215-8.

    Giacoppo, S., Galuppo, M., Pollastro, F., Grassi, G., Bramanti, P., & Mazzon, E. (2015). A new formulation of Cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis. DARU Journal of pharmaceutical sciences, 23(1), 1-17.

    McPartland, J. M., Duncan, M., Di Marzo, V., & Pertwee, R. G. (2015). Are Cannabidiol and Δ9‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. British journal of pharmacology, 172(3), 737-753.

    Nicola Boulton
    Nicola Boulton

    Also in CBD Beauty

    10 Best CBD Skincare Products for 2022
    10 Best CBD Skincare Products for 2024

    by Nicola Boulton October 13, 2022 11 min read

    Read More
    10 Best CBD Cream for Pain Relief for 2022
    10 Best CBD Cream for Pain Relief for 2024

    by Nicola Boulton October 13, 2022 12 min read

    Read More
    10 Best CBD Beauty Products for 2022
    10 Best CBD Beauty Products for 2024

    by Nicola Boulton October 12, 2022 11 min read

    Read More