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  • by Nicola Boulton September 27, 2022 6 min read

    CBD Affects the Brain: How Does It Work?

    Unlike other compounds of the cannabis plant, CBD especially interacts with the nervous system. For that essence, most people have been captivated by this product and concluded to use it for different medical purposes. Are you among such individuals who have taken such a reasonable step?

    Cannabidiol is effective in ensuring one's good health and good functioning of the nerves. One of the reasons most individuals have decided to use CBD in their life is its importance to the brain. CBD can be used for different purposes. Other importance of Cannabidiol includes and are not limited to treating chronic pain, reducing stress and anxiety, and boosting appetite. This article will enable one to understand how useful CBD is to the brain to try it out. One will also know to have wider thinking on the legalization of cannabis compounds, side effects, and benefits associated with cannabidiol use. It is advisable to ensure one's application method to enjoy CBD benefits; hence the article will give out methods of applying CBD.

    CBD Vs. THC

    According to Johnson et al. (2021), CBD, also known as Cannabidiol, is manufactured from the cannabis Sativa plant or hemp flower. Cannabidiol is one of the 100 and above compounds found in the cannabis plant. Despite more compounds in the cannabis plant, Cannabidiol remains the most exploited. This is because of the more benefits it offers to the body system. THC is also a compound of the cannabis plant, which is responsible for the 'high' feeling felt after smoking marijuana. Moreover, it leads to addiction and overdependence when cannabis is smoked for a long. Cannabidiol gives the benefits intended by an individual without any weird feelings.

    CBD Glossary

    There are three types of Cannabidiol: full-spectrum, broad-spectrum, and CBD isolate. They are identified according to the compounds and THC level used during manufacture. The types of CBD can be discussed below:

    Full-Spectrum CBD

    This type of CBD is made up of all the compounds of the cannabis sativa plant with at least 0.3% of THC. Due to more compounds it has, according to Maayah et al. (2020), full-spectrum Cannabidiol has the most health benefits among other types. It is used to treat autoimmune diseases, treat cancer symptoms and reduce chronic pain. However, it has an earthy smell and taste, making it unsuitable for first cannabidiol users. It may be used only with regular cannabidiol users.

    Broad-Spectrum CBD

    Broad-spectrum CBD  is made up of all the compounds of cannabis sativa except THC. One can enjoy the benefits of CBD without any weird feeling when broad-spectrum is taken. It treats diseases that provoke one's immunity, like arthritis and diabetes. According to Legal et al. (2022), broad-spectrum CBD can be used to treat skin cancer, alleviate chronic pain, and boost sleep.

    CBD Isolate

    CBD isolate is the purest form of CBD made from none of the compounds of cannabis sativa or hemp plant. Due to no chemicals contained, the isolate does not have an earthy smell or weird taste. Therefore, it is suitable for the first CBD consumers since they may not put up with the earthy smell and the weird taste. One can incorporate CBD isolate in food or drink to treat infections, relieve chronic pain or boost sleep. However, it may not be suitable for those who intend to have immediate and more effects.

    How to Apply CBD to Brain Effects

    An individual may buy CBD but does not know the different methods one can use when applying CBD. each cannabidiol user must know different forms available in nearby stations, dispensaries, or gas stations. The forms of CBD included tinctures, oils, gummies, edibles, and CBD vapes. Tinctures and oils can be applied similarly, involving none other than topical application. This is where these forms are applied on the skin surface to bring an effect. A person can chew cannabidiol gummies just as one may do to a piece of ball gum. When a person decides to have edibles as best chosen, it will go the easier way of consuming since it has already been incorporated into food and drinks. In contrast, CBD vapes can be smoked or inhaled for effectiveness. They are easily absorbed into the bloodstream.

    How Does CBD Affect Brain Receptors?

    The receptors in the body help to bring a change towards a stimulus. They are responsible for maintaining the internal environment, a process known as homeostasis. The following is how the brain is affected by CBD consumption:

    Boost Anandamide

    This lipid mediator acts as an endogenous ligand for the body's endocannabinoid receptors. It has the same component as THC, thus responsible for addiction and dependence on the drug. According to Boggs et al. (2018), when one uses Cannabidiol combined with tetrahydrocannabinol, the concentration of anandamide increases, facilitating perceiving pain and maintaining body temperature.

    Vanilloid Receptors

    It is a receptor that acts as an anti-inflammatory. Shannon et al. (2015)  showed that CBD stimulates vanilloid, helping prevent inflammation in different body parts.

    CBD with Serotonin

    Serotonin is a receptor that determines one's mood, pain perception, and cognition. They release hormones that help to perform the above functions. They also affect body weight since they can be used to treat obesity. Basso et al. (2017) stated that Cannabidiol stimulates serotonin to release hormones for the above purposes.

    Medical Importance of CBD to the Brain

    A person would like to know the importance of medical importance of CBD to the brain to compel one to explore it. Here is the medical importance of CBD for one's health:

    • According to Forsythe et al. (2022), CBD helps to manage neurological chaos like stress, depression, and anxiety
    • According to Shannon et al. (2016), CBD can treat insomnia. This may result from one being stressed or anxious, hence losing sleep. CBD stimulates the body's endocannabinoid receptors that help one to achieve sleep.
    • Helps in the management of neuropsychiatric conditions.

    Side Effects of CBD

    The following are dangers that one may be exposed to as a result of misuse of CBD:

    • Dry mouth
    • Diarrhea
    • Interference with appetite
    • This leads to addiction and over-dependence

    Other Benefits of CBD

    Apart from managing brain infections, here are other benefits of CBD:

    • Treat autoimmune diseases
    • Manage chronic pain
    • Boost appetite
    • Maintain the heart in good health
    • Treat nausea


    The brain determines the personality and behavior of an individual. The brain should be maintained in good condition for the effective performance of receptors and hormones. Cannabidiol has been found to contribute to the effective performance of the receptors and provide medical importance to the brain. One should consider using CBD and its product for the brain's good effects and tremendous performance. It is important to know how CBD and its products can be applied to enjoy the benefits of Cannabidiol on the brain. A person can enjoy more benefits from Cannabidiol; one should embrace such benefits. However, there are some risks and side effects associated with such compounds; hence one should be careful to consume them effectively.


    Basso, J. C., & Suzuki, W. A. (2017). The Effects Of Acute Exercise On Mood, Cognition, Neurophysiology, And Neurochemical Pathways: A Review. Brain Plasticity, 2(2), 127-152.

    Boggs, D. L., Nguyen, J. D., Morgenson, D., Taffe, M. A., & Ranganathan, M. (2018). Clinical And Preclinical Evidence For Functional Interactions Of Cannabidiol And Δ9-Tetrahydrocannabinol. Neuropsychopharmacology, 43(1), 142-154.

    Forsythe, M. L., & Boileau, A. J. (2022). Use Of Cannabinoids For The Treatment Of Patients With Post-Traumatic Stress Disorder. Journal Of Basic And Clinical Physiology And Pharmacology, 33(2), 121-132.

    Johnson, M. S., & Wallace, J. G. (2021). Genomic And Chemical Diversity Of Commercially Available High-CBD Industrial Hemp Accessions. Frontiers In Genetics, 12, 1160.

    Legal, I. C. (2022). CBD Benefits: What CBD Might Help With And Potential Uses For CBD. Sign, 55.

    Maayah, Z. H., Takahara, S., Ferdaoussi, M., & Dyck, J. R. (2020). The Molecular Mechanisms Underpin The Physical Benefits Of Full-Spectrum Cannabis Extract In Treating Neuropathic Pain And Inflammation. Biochimica Et Biophysica Acta (BBA)-Molecular Basis Of Disease, 1866(7), 165771.

    Shannon, S., & Opila-Lehman, J. (2015). Cannabidiol Oil For Decreasing Addictive Use Of Marijuana: A Case Report. Integrative Medicine: A Clinician's Journal, 14(6), 31.

    Shannon, S., & Opila-Lehman, J. (2016). Effectiveness Of Cannabidiol Oil For Pediatric Anxiety And Insomnia As Part Of Posttraumatic Stress Disorder: A Case Report. The Permanente Journal, 20(4).


    Nicola Boulton
    Nicola Boulton

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