CBD Clinical Study Results

What does the clinical study say about CBD? What is a type of CBD available in the health field? How much CBD should one take? What are the clinical results on the benefits and side effects of CBD? The article answers the above queries and explains which CBD controls chronic diseases.

CBD has quickly become a center of attention in medical studies. It doesn't make users feel high when consuming it. CBD has no chemical dependency on users (no medical addiction). CBD has endless health benefits, from curing chronic pain, stress, and anxiety to managing symptoms of chronic diseases like cancer, arthritis, Acne, Parkinson's, and Alzheimer's. However, since CBD has recently entered the medical field, people must explore various CBD medical questions. Studies focused on the role of CBD on endocannabinoid receptors in the body and how it boosts the brain's functions in regulating inflammation and pain.

What Do Clinical Studies Say About CBD?

Nelson et al. (2020) stated that CBD is an active chemical compound extracted from the leaves and flowers of cannabis/hemp plants. It is the second most common active cannabinoid known within the cannabis plant. Tetrahydrocannabinol  (THC)  is the common cannabinoid mostly associated with marijuana users. It is psychoactive and thus provides a feeling of highness to its user, meaning it interferes with the human system's psychological and physical states. CBD is non-psychoactive and non-intoxicating; hence, it has various health benefits for its users. It is derived from hemp to be used in medical treatment. It has a long history in treating people suffering from chronic diseases, particularly patients who cannot harness the benefits of traditional or other medications due to damaged organs or a compromised body immune system.

CBD exists over the counter or in pharmacies in three states. Suraev et al. (2020) explained that manufacturers use different extraction methods, from CO₂ extraction, and solvent extraction to alcohol extraction techniques resulting in three types of CBD compounds in the product:

CBD Isolate

It is the pure type of CBD since it contains no other cannabinoid contamination except CBD compounds. CBD compounds are isolated from other natural compounds of the cannabis plant during extraction.

The purity level is the biggest benefit of CBD isolates since the potency of CBD, when infused with other stuff like foods, lotions, or oil, does change. Therefore, it is highly beneficial to the health field, mostly to minors or individuals who want a pure CBD state, by avoiding probably highness caused by THC.

Full-Spectrum CBD

It contains all cannabinoids of the cannabis plant, including traces of THC. The most common cannabinoids in the CBD type are terpenes and flavonoids, which can have their benefits. Although it is contaminated with THC, most manufacturers are regulated by the Food and Drug Administration (FDA)  to produce products with less than 0.3%of THC levels.

Clinical research elaborates that some people prefer taking full-spectrum  CBD over isolate because of the entourage effect theory, which explains that taking CBD with THC and other cannabinoids is more effective than taking isolated cannabidiol.

Broad-spectrum CBD

Broad-spectrum contains CBD compounds alongside small amounts of cannabinoids except for THC.

It mostly heightens the effects of CBD because it contains medicinal terpenes like pinene and myrcene. The majority prefer it since it provides entourage effects without necessarily consuming THC.

CBD Medical Studies Result

Cannabis-derived products have been in contact with humans for centuries, but people know relatively small details about their medicinal applications, especially CBD. Doctors have concluded how CBD affects the perception of pain and inflammation. Also, results can tell the safe doses of CBD and potential side effects of  CBD.

Dosage

Silmore et al. (2021) stated that starting with small doses is advisable and gradually grows with time. When you consume CBD gummies and capsules or apply CBD topical, it is hard to control the amount of CBD compounds in the product. These products don't offer much dosage flexibility since you can't split the products or isolate the CBD compounds.

CBD oil makes it easier to begin and control dosage. Using tinctures and droppers, you can calculate the dosage you are taking. In most hospitals or medical pharmacies, CBD is offered in bottles with droppers, and the total liquid volume and CBD content are labeled.

Clinical Benefits of CBD

Pamplona et al. (2018) revealed that CBD could help control and manage diseases such as cardinal disease, arthritis, Acne, Parkinson's, Alzheimer's, epilepsy, ADHD, cancer, GAD, diabetes, and PTSD. These are because it shows the following effects;

It Alleviates Pain and Inflammation

CBD has anti-inflammatory properties. When consumed, it interacts with body receptors which receive pain and inflammation stimuli. CBD helps people with arthritis, cancer, and epilepsy to cope with pain and a high level of inflammation.

Reduction of Anxiety and Depression

CBD controls the main symptoms of GAD, PTSD, and ADHD: stress and chronic anxiety. It is an antidepressant, meaning it controls the production of the Serotonin hormone, which regulates body stress. Additively it reacts with body ECS which helps tackle anxiety and manipulate the brain in how it handles anxiety thoughts.

Treating Skin Conditions

Fischer (2021) suggested that CBD is applied to the skin; it helps moisturize, cleanse, and reduce itching, pain, and inflammation associated with Acne, eczema, psoriasis, and arthritis disorders.

It Lowers Blood Pressure

Wayne et al. (2020) showed a single dose of CBD lowers blood pressure by 6 mmHg, ultimately reducing the risk of cardinal problems and controlling cancer-related blood pressure.

Lowering Insulin Levels

CBD helps in managing diabetes, whereby it lowers the body's sugar level due to its insulin-resistance properties.

Symptoms Related to Cancer Treatment

Massi et al. (2013) suggested that CBD slows the growth of cancer cells,  lowering tumor growth. It also manages symptoms associated with cancer treatment side effects such as nausea and vomiting, making patients not quit the prescribed medication. Learn more about benefits of hemp

Improve Quality Sleep

it is well known that marijuana users claim to have relaxing feelings that help manage their sleeping disorders. CBD is a cannabis-derived compound; therefore, research shows it has a calming effect on its user for sleeping and alertness during the day, stabilizing sleeping patterns.

Potential Side Effects

CBD, when used frequently with other medication or under uncontrolled dosage, can result in the following effects:

• Dry mouth
• Diarrhea
• Loss of appetite
• Weight changes

Conclusion

CBD has no regulation from the Food and Drug Administration; therefore, it is important to understand what CBD capabilities' are in health issues. Medical studies have shown that CBD can be used in treating various diseases such as epilepsy, Acne, cancer, insomnia, Parkinson's, etc. however, there is a regulation in dosage. Clinical trials show that the maximum dosage per day ranges from 100 to 800Mg. Clinical studies are now uncovering how to minimize the side effects of CBD and ensure safety when used with prescribed medication.

References

Fischer, K. (2021). The Healthy Skin Kitchen: For Eczema, Dermatitis, Psoriasis, Acne, Allergies, Hives, Rosacea, Red Skin Syndrome, Cellulite, Leaky Gut, Mcas, Salicylate Sensitivity, Histamine Intolerance & More. Exisle Publishing.

Massi, P., Solinas, M., Cinquina, V., & Parolaro, D. (2013). Cannabidiol As Potential Anticancer Drug. British Journal Of Clinical Pharmacology, 75(2), 303-312.

Nelson, K. M., Bisson, J., Singh, G., Graham, J. G., Chen, S. N., Friesen, J. B., ... & Pauli, G. F. (2020). The Essential Medicinal Chemistry Of Cannabidiol (Cbd). Journal Of Medicinal Chemistry, 63(21), 12137-12155.

Pamplona, F. A., Da Silva, L. R., & Coan, A. C. (2018). The Potential Clinical Benefits Of Cbd-Rich Cannabis Extracts Over Purified Cbd In Treatment-Resistant Epilepsy Are Observational Data Meta-Analysis. Frontiers In Neurology, 759.

Schonhofen, P., Bristot, I. J., Crippa, J. A., Hallak, J. E. C., Zuardi, A. W., Parsons, R. B., & Klamt, F. (2018). Cannabinoid-Based Therapies And Brain Development: Potential Harmful Effect Of Early Modulation Of The Endocannabinoid System. Cns Drugs, 32(8), 697-712.

Silmore, L. H., Willmer, A. R., Capparelli, E. V., & Rosania, G. R. (2021). Food Affects The Formulation, Dosing, And Administration Of Cannabidiol (Cbd) In Humans: A Systematic Review Of Clinical Studies. Pharmacotherapy: The Journal Of Human Pharmacology And Drug Therapy, 41(4), 405-420.

Suraev, A. S., Marshall, N. S., Vandrey, R., Mccartney, D., Benson, M. J., Mcgregor, I. S., ... & Hoyos, C. M. (2020). Cannabinoid Therapies In The Management Of Sleep Disorders: A Systematic Review Of Preclinical And Clinical Studies. Sleep Medicine Reviews, 53, 101339.

Wayne, P., Bernstein, C., Kowalski, M., Kamila, O., Connor, J., Vining, R., ... & Rist, P. Icimh 2020 Abstracts.