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  • by Nicola Boulton September 07, 2022 6 min read

    What Is THC-O? Meet This New Powerful Hemp Cannabinoid

    Do you know what THC-O is? Here is what you need to know: what THC-O acetate is, what THC acetate is if THC-O acetate is legal, what THC-O acetate feels like, and why it is becoming popular daily.

    Following the 2018 law Bill, which legitimized hemp farming, there has been an influx of legal hemp-based products. In addition to non-intoxicating cannabidiol, which is easily extracted and occurs naturally in hemp plants, many synthetic cannabinoids have been produced by exposing cannabidiol to various synthetic procedures. THC-O is one of the most recent cannabinoids discovered. It follows in the strides of other new cannabinoids and delta 8 THC in the marketplace. Some of these chemicals occur obviously in very minute amounts in cannabis plants, while others do not. They all have a presence on the legal market since producers have discovered how to mass-produce them from legal hemp plants. Below is more about THC-O.

    What is THC-O Acetate?

    The acetate ester form of tetrahydrocannabinol is known as THC-O and O-acetyl-nine-THC or THC acetate ester. Experts refer to it as THC-O acetate, but nearly everyone refers to it as THC-O. When writing it, some people omit the hyphen and write THCO or THC O. It is pronounced "THC-oh" regardless of how you spell it; that's the letter O,

    THC-O is synthetic, very similar to delta-nine tetrahydrocannabinol. This psychoactive substance predominates in marijuana plants, as are delta ten THC and the other cannabinoids generated from hemp that are commercially available. Delta et al. (2021) stated that though its effects are extremely similar to delta-nine, THC-O is more intoxicating than delta ten, HHC, or delta eight, and even more potent than delta-nine tetrahydrocannabinol because it attaches to the body's cannabinoid sensory receptors more firmly than the other forms of tetrahydrocannabinol.

    Every standard cannabis product style, including vapes, oils, edibles, and flowers, is offered by THC-O. Disposable vapes and THC-O vape carts are available for purchase with either unflavored distillate or flavoring terpenes. Additionally, tinctures containing edible oils like MCT and THC-O are made. Chocolates and gummies are only a couple of the THC-O edibles that are offered. The last option is the THC-O flower, just hemp flower laced with THC-O.

    How is THC Acetate Made?

    THC-8 or THC-9 can be used to make THC-O Acetate. You have to make Delta-8, a THC isomer, first. This is accomplished by refluxing hemp-derived cannabidiol with another acid or p-toluene sulfonic acid that acts as a stimulant in a natural solvent, such as heptane or toluene. When you have Delta-8, you can transform it into THCO.

    THC-O Acetate is an acetylated version of Tetrahydrocannabinols, not a naturally existing substance in cannabis plants. In medicines, acetylated substances like THC-O are common. The Chemical Society cites the example of acetylating heroin from morphine, but it is an alarming example. Aspirin, produced by scientists by acetylating salicylic acid, is another less alarming illustration.

    Is THC-O Acetate Legal

    Hemp is defined under the Farm Bill as all cannabis plant components, including isomers and derivatives, with a Delta-9 THC content of less than 0.3%. Delta-8 is a derivative as well as an isomer. Despite not being an isomer, THC-O acetate is a legally recognized derivative. If you are highly active with the hemp law, pay attention to the language of the law.

    States like Florida strictly adhere to the USDA's bill to maintain consumer access to hemp by-products like THC-O A and Delta-8. Despite the federal verdict, some states have added additional language to their laws to allow them to outlaw Delta-8.

    Some States approved legislation that outlawed both, while others merely outlawed Delta-8-THC. That implies that hemp brands have the chance to launch a newly legal by-product on the market, at least until the parliamentary session of the next year.

    How Does THC-O Acetate Feel Like?

    Each person's biochemistry is unique, and they all suffer various neurological impacts. You can only comment on what you know. However, you find that THC-O Acetate vapes are smoother than Delta-8. Pure Delta-8 is pleasant, but inhaling THC-O A feels like it produces a more comprehensive cannabis profile and is as easy as breathing in nothing.

    Delta-8 seems to be more supplemental. Verhoeven et al. (2020) noted that people take it to treat their shoulder pain and feel much better physically. Because it contributes to more focus, they also take it during the day. On the other hand, it not only has a physiological effect but also completely uplifts the mood. It's not psychedelic, but it has a classic euphoric impact. Since it is so calming, it is also more of an evening substance. As a result, the recipe strikes me as being very much a real hybrid. It most closely resembles the marijuana strain Pineapple Express.

    Why Is It Becoming Popular?

    Despite having just recently entered the cannabis sector, THC-O is one of the most widely used synthetic substances, and drug users are obsessed with its high. THC-O vendors also operate around the clock to accommodate client demand for different goods.

    The following are some key arguments favoring THC-O over other chemical constituents of the marijuana plant and artificial substances with a similar molecular make-up for cannabis consumers. The effects of the substance are stronger than those of other components found in marijuana plants, such as delta-9 THC. One analytical lab analysis claims that some cannabis product manufacturers add vitamin E acetate to THC vape items to increase potency. Yang et al. (2014) established that THC that has been acetylated, such as THC O, is more potent than THC that has not been altered.

    Anecdotal data says that THC O is the most potent cannabinoid in the marijuana and hemp markets, going beyond the physically sedative effects to induce psychedelic experiences. Cormack & Cosgrave (2021) stated that many cannabis users are drawn to the psychedelic experience, which is why there has been a strong shift into the THC-O market.

    Second, THC O is legal under federal law as a hemp-derived product, unlike delta-9 THC, an illicit narcotic that is only authorized in a few states. As a result, individuals who live in states where delta-9 THC is illegal can ingest THC-O without risk of legal ramifications. This compound has metabolites resembling delta-9 THC and may appear in drug tests.

    Third, THC-O is cheap and widely accessible compared to delta-9 THC goods. As a result, the price is a key factor in encouraging new THC users to try THC-O products.


    THC-O has numerous properties that make it pleasant to consume. However, there is still a shortage of studies on its therapeutic advantages and short- and long-term impacts. Consider using the synthetic cannabinoid sparingly while learning more about its effects. Only buy lab-tested delta-8 THC-O products to prevent negative effects from impurities. The THC-O molecule, however, exerts its effects in a manner comparable to that of other cannabinoids found in hemp and marijuana plants. It binds to the ECS receptors in the body to produce various effects. The therapeutic advantages of THC-O products, such as stress reduction, pain alleviation, and hunger stimulation, are that it has effects nearly identical to those of delta-9 THC and other THC analogs.


    Cormack, P., & Cosgrave, J. (2021). "Enjoy Your Experience": Symbolic Violence And Becoming A Tasteful State Cannabis Consumer In Canada. Journal Of Consumer Culture, 1469540521990876.

    Delta, D., Ages, T. C. V. C., & So Inaccurate, W. A. C. (2021). CBD Oracle Lab Study Shows Some Delta-8 Products Are 7700% Over The Legal Delta-9 THC Limit We Got 51 Hemp-Derived Delta-8 THC Products Tested By An Independent Lab And Found High Levels Of Delta-9 THC In Most Of Them. And That Was Just The Beginning. Delta.

    Verhoeven, V., Tsakitzidis, G., Philips, H., & Van Royen, P. (2020). Impact Of The COVID-19 Pandemic On The Core Functions Of Primary Care: Will The Cure Be Worse Than The Disease? A Qualitative Interview Study In Flemish Gps. BMJ Open, 10(6), E039674.

    Yang, X., Hegde, V. L., Rao, R., Zhang, J., Nagarkatti, P. S., & Nagarkatti, M. (2014). Histone Modifications Are Associated With Δ9-Tetrahydrocannabinol-Mediated Alterations In Antigen-Specific T Cell Responses. Journal Of Biological Chemistry, 289(27), 18707-18718.

    Nicola Boulton
    Nicola Boulton

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