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  • by Nicola Boulton September 15, 2022 5 min read

    What Are the Side Effects of CBG?

    CBG, also known as cannabigerol, is one of the cannabinoids in the cannabis plant. Taking in large amounts may lead to adverse effects such as fatigue and diarrhea. This article explains what CBD is, how CBG works in the body, the side effects of CBG and how to prevent CBG side effects.

    CBG, also referred to as cannabigerol, is one of the chemical compounds in the cannabis plant. With the upcoming sophisticated cannabis extraction methods, CBG is becoming an essential supplement in the health and wellness industry. Though it is a lesser-known cannabinoid than cannabidiol (CBD) and tetrahydrocannabinol (THC), scientists are intensifying their research on its potential benefits and side effects. However, if you are thinking about adding this product to your daily routine, that's a great idea. However, be aware if misused, it can cause various side effects.

    Understanding CBG

    According to Sepulveda et al. (2022), CBG, also known as cannabigerol, is one of the cannabinoids exiting the hemp plant. It is a lesser-known chemical compound since it is solely available in mature plants and in small quantities not exceeding 0.1 percent. However, it is an important cannabinoid since it is a precursor to multiple cannabinoids, THC and CBD. There are various CBG products, including but not limited to; capsules, tablets, oils, and vapes.

    How CBG Works in the Body

    Farrelly et al. (2021) stated that, like other chemical compounds, CBG works by interacting with the body's endocannabinoid system (ECS). This system contains various receptors, enzymes, and endocannabinoids. Endocannabinoids are compounds produced naturally by the body and interact with the CB1 and CB 2 receptors. Dumas et al. (2021) commented that the Endocannabinoid's role is to manage various physiological functions like appetite, memory, and sleep and maintain the body's balance. The CB1 receptors are present in the central nervous system, whereas the CB2 receptors are in the immune system. CBG binds to the CB1 and CB2 receptors, activating them to enhance anandamide. Anandamide is a neurotransmitter that influences various activities, such as pain and motivation. Once it interacts with the CB1 receptor, CBG increases anandamide levels. CBG also affects serotonin receptors, mainly the 5HT1A receptor. This receptor moderates serotonin levels.

    What Are the Side Effects of CBG?

    CBG can lead to side effects like any other product when taken in immoderate amounts. Knowing the side effects of a product beforehand helps you regulate your routine much more effectively. Some of its side effects include:


    Ay et al. (2018) suggested that diarrhea is a significant side effect caused by any CBG product. The reason is that your digestive system signals that you've taken too much of the product and can't sustain it. Hence the reason your gut may react to the intake or not. Another reason is that the stomach reacts unexpectedly if your body is unfamiliar with a product. An excellent solution to this side effect is avoiding CBD products such as oils and edibles since they contact the digestive system.


    Fatigue is another common side effect of consuming CBG. It affects almost nine out of twelve. Most people consume CBD due to sleeping problems such as insomnia. Some users noted that tiredness might be a welcoming side effect of CBG since it showed that the compound worked effectively. Taking larger doses of CBG is prohibited since it may lead to grogginess and fatigue, which may interfere with your productivity. Hence, consuming CBG while sleeping is advisable since you will rest in case fatigue strikes.

    Changes in Appetite

    Most individuals have reported a change in appetite once they began taking CBG. CBG products are made with various ingredients. Some may boost appetite, while others repress it. However, effects vary in everyone due to unique body chemistries. Larger CBG doses may increase your appetite or suppress it. However, you do not have to worry since this phase will be over once the compound leaves your system.

    Dry Mouth

    Most cannabis products cause dry mouth, CBG included. However, it does not symbolize dehydration as many individuals presume. Taking CBG can interfere with their saliva production ability hence the reason dry mouth may be experienced. However,  if you are new to CBG and have experienced dry mouth, you should increase your water intake or wait until it leaves your system entirely.

    Changes in Weight

    Since CBG affects appetite, you may become hungrier or less hungry depending on your body's mechanisms. It may lead to a weight shift. However, there is nothing to worry about since you can regulate your appetite but remember not to overdo it.

    How to Prevent CBG Side Effects

    Take It in the Required Amount

    Most CBG side effects are caused when taken in more significant amounts. Therefore taking it in the required dose and ensuring it does not interact with the digestive is one of the ways you can avoid most of its side effects. Always follow the product's instructions. Utilize the product in the suggested way and notice if it may lead to any developments. While you experience any adverse effects, contact your doctor immediately.

    Purchase Your CBG Product from a Reputable Brand

    Below are some of the things you should look out for in a brand:

    The Extract Sourcing

    CBG should only be extracted from the hemp plant, not marijuana. Also, its THC levels should not exceed 0.3 percent.

    How the Hemp Plant Was Cultivated

     Ensure that the hemp plant uses sustainable production methods. Also, it should be free from contaminants and pesticides since they may lead to various health issues.

    Proof of Third-Party Lab Test Results

    A transparent brand should always have third-party lab test reports. This report confirms the cannabinoids levels, presence of contaminants, and product safety and quality.

    Do Not Take CBG While Under any Other Medication

    CBG is broken down in the liver like various prescribed medications. When consuming it, the liver may work overtime leaving higher drug concentrations in your system, which may be toxic. You should always consult a health care provider before taking CBG, especially if you are under any other medications.

    Does CBG Cause the High Effects?

    CBG interacts with the cannabinoid receptors, although it does not necessarily mean it has the same psychoactive effects as THC. According to some users consuming higher amounts of CBG may lead to mild psychoactive effects.


    Since everyone's body is unique, it is normal to experience various side effects. CBG is one of the chemical compounds naturally existing in the cannabis plant. When consumed in large amounts, it may lead to adverse effects such as diarrhea, tiredness, changes in weight, and appetite. However, to prevent these side effects, you; consume it in the right amount, not take it if under any other medication, and purchase from a reliable brand since they offer high-quality products. Additionally, always consult your doctor before incorporating it into your daily supplement regime.


    Ay, S. S., ÖNYAY, F., SARAL, G., Duygu, K. A. Y. A., Aslan, S., & Findik, M. (2018). The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 24(4).

    Dumas, S. J., Meta, E., Borri, M., Luo, Y., Li, X., Rabelink, T. J., & Carmeliet, P. (2021). Phenotypic diversity and metabolic specialization of renal endothelial cells. Nature Reviews Nephrology, 17(7), 441-464.

    Sepulveda, D. E., Morris, D. P., Raup‐Konsavage, W. M., Sun, D., Vrana, K. E., & Graziane, N. M. (2022). Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy‐induced peripheral neuropathy. European Journal of Pain.

    Farrelly, A. M., Vlachou, S., & Grintzalis, K. (2021). Efficacy of phytocannabinoids in epilepsy treatment: novel approaches and recent advances. International Journal of Environmental Research and Public Health, 18(8), 3993.

    Nicola Boulton
    Nicola Boulton

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