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  • by Nicola Boulton December 13, 2023 4 min read

    How Long Does CBD Cream Take to Work?

    Research shows that Cannabidiol (CBD) creams can relieve pain and reduce inflammation, hence beneficial to people with arthritis and such conditions. The cream is applied directly to the skin, making it efficient and easy to interact with the nerves under the skin. This article will discuss CBD in detail, including forms of CBD, the mechanism of action of CBD cream, benefits of CBD cream, how to use CBD cream, types of Cannabidiol cream, and frequently asked questions regarding the cannabis-infused cream.

    Cannabidiol-infused creams are one of the most common forms of consuming CBD compounds. Clinical studies have shown the potential benefits of CBD compounds in treating different diseases and disorders. CBD topicals like cream and lotion are used to relieve pain caused by migraines and arthritis. The cream is administered topically, which easily kicks in compared to some other forms of Cannabis-infused products. In many cases, the topical takes a few minutes to manifest its effects, although the duration is a function of many factors including, but not limited to, CBD's potency. 

    What Is CBD Cream?

    Cannabidiol, abbreviated as CBD, is one of the most common cannabinoids found in cannabis plants and can also be artificially made. It gives the cannabis plant its smell and taste. Creams are commonly made of water and oil. In this case, CBD creams are infused with Cannabidiol oil.

    The cannabis topicals are applied directly to the skin for localized conditions.

    How CBD Cream Is Made

    The process starts by extracting CBD oil from the hemp plant. The main ingredients for making creams are water and oil. Since Cannabidiol oil cannot mix with water, an emulsifier agent is needed. The desired product determines the ratio of the emulsifier to the ingredients. Other flavors can be added, like peppermint, lavender, and aloe Vera.

    How CBD Cream Works and How Long It Takes To Work

    Cooray et al.(2020) suggested that CBD interacts with the endocannabinoid system (ECS). ECS has cannabinoid receptors CB1 and CB2 located all over the body. The receptors regulate the activities of neurotransmitters. In the skin, the concentration of cannabinoid receptors is high. Cannabidiol weakly interlinks with CB1 and CB2 releasing different effects. CBD cream applied on the skin is absorbed quickly by tensioned muscle, where it interacts with the CB2 receptors. Baswan et al. (2020) stated that CBD has anti-inflammatory, antibacterial, antifungal, and anti-oxidative properties. It may help with skin problems like redness, acne, aging wrinkles, dry skin, and itching.

    CBD may take about 20 minutes to be absorbed in the skin and dispense its effect, depending on the type of CBD oil present in the cream.

    Benefits of CBD Cream

    •  Peyravian et al. (2022)argued that Cannabidiol cream blocks glands that produce oil, reducing acne. It also has anti-inflammatory properties, which suppress pain related to acne.
    • Lowin et al. (2020)stated that arthritis causes inflammation and pain. CBD oil has anti-inflammatory elements that can help people suffering from arthritis. 
    • CBD cream is a skin moisturizer; it interacts with cannabinoid receptors, transmitting messages to the sebaceous glands.
    • Clinical studies have proven that CBD cream is a pain reliever. It helps in Inflammatory caused pains.

    How Long Does CBD Cream Last in the Body?

    Most research suggests that CBD stays in your body for two to six hours. However, some factors affect how long it stays in the body. These factors include; the amount of cream used, how often the cream is applied, and your body's interaction with it. Creams offer more instant effects compared to methods like edibles.

    What Type of CBD Cream Is More Effective?

    Different types of CBD determine the effectiveness of the cream. There are no less than three different types of CBD oil;

    • Full-spectrum CBD cream- this is said to be the best as it is a combination of all cannabinoid compounds. The compounds work together and give the best effectiveness.
    • CBD isolates cream- it is pure CBD. It has at least 99 percent purity in most cases. The isolate is preferred by users who want to enjoy CBD elements alone for better effectiveness.
    • Broad-spectrum cream- the cream has most cannabinoid compounds except THC. The broad-spectrum is the ideal dosage for people who want to experience terpene, flavonoids, and other compounds without THC.

    How to Choose CBD Cream


    Quality Cannabidiol cream has third-party laboratory testing to verify the product. Different types of CBD as well have different qualities. It is also easier to tell by the price of the cream.

    Method of Extraction

    The purity of the CBD compounds is determined by the method of extraction used; the CO2 extraction technique provides the safest cannabis products.

    Customer Reviews

    Consumers will genuinely tell the truth about the product. Before trying, it is important to look at the reviews from people's experiences with the product; positive reviews indicate that it is safe to use.

    Brand’s Reputation

    Companies with good reputations sell their products in licensed dispensaries or online. 

    Additional Ingredients in the Cream

    People react differently to elements. Some ingredients may irritate others; hence it is important to consider what is best for you. 


    Two to six hours is the potential time for the effectiveness of CBD cream in the body. About Cannabidiol products, it is still on the winds. Most research has tested animals and suggests it is possible for humans too. There is limited information on CBD creams and other forms of Cannabidiol. However, people have reported positive from cannabis-infused products. Others suggest that it is unsafe due to its side effects. One should go for products from reputable brands which offer high-quality products. 


    Baswan, S. M., Klosner, A. E., Glynn, K., Rajgopal, A., Malik, K., Yim, S., & Stern, N. (2020). Therapeutic Potential Of Cannabidiol (CBD) For Skin Health And Disorders. Clinical, Cosmetic And Investigational Dermatology, 13, 927.

    Cooray, R., Gupta, V., &Suphioglu, C. (2020). Current Aspects Of The Endocannabinoid System And Targeted THC And CBD Phytocannabinoids As Potential Therapeutics For Parkinson’s And Alzheimer’s Diseases: A Review. Molecular Neurobiology, 57(11), 4878-4890.

    Lowin, T., Tingting, R., Zurmahr, J., Classen, T., Schneider, M., &Pongratz, G. (2020). Cannabidiol (CBD): A Killer For Inflammatory Rheumatoid Arthritis Synovial Fibroblasts. Cell Death & Disease, 11(8), 1-11.

    Peyravian, N., Deo, S., Daunert, S., & Jimenez, J. J. (2022). The Anti-Inflammatory Effects Of Cannabidiol (CBD) On Acne. Journal Of Inflammation Research, 15, 2795.


    Nicola Boulton
    Nicola Boulton

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