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  • by Nicola Boulton August 29, 2022 6 min read

    CBD Oil for Rheumatoid Arthritis Pain Relief

    Did you know cannabidiol oil can relieve rheumatoid arthritis pain? This article discusses the following:  cannabidiol oil, cannabidiol oil for rheumatoid arthritis, cannabidiol oil and arthritis pain relief, cannabidiol and chronic pain, cannabidiol oil, and side effects of CBD oil.

    Rheumatoid arthritis is a form of arthritis caused by an autoimmune condition that produces inflammation in different body areas. This condition most frequently affects joints in the hands, knees, and wrists, leading to inflammation in the damaged joint linings and causing damage to the tissue of the joints. Damage to tissues can result in lung, eyes, heart problems, and chronic pain.

    CBD oil is used in treating various medical conditions, including obesity, and is currently the subject of research in modern science. Moreover, several studies have demonstrated that CBD oils are effective in lowering levels of stress and enhancing the quality of sleep. This article explains how you can use CBD Oil to treat rheumatoid arthritis.

    CBD Oil for Rheumatoid Arthritis Pain Relief

    CBD Oil

    CBD oil is extracted from the flowers, leaves, and stems of hemp and cannabis plants. It comes in three formulations: full spectrum, broad spectrum, and isolate. CBD is considered safe because it has traces of THC or none depending on the type of oil. Thus, it does not have psychoactive effects.

    There is a wide variety of CBD oil products on the market, and the amount of CBD contained may vary in each product. Consumers should read the labels carefully to determine the amount of oil contained.

    The Farm Bill legalized using CBD, which has less than 0.3 percent of the psychoactive compound tetrahydrocannabinol (THC). According to Ghasemi et al.  (2022), most people use cannabidiol oil to treat pain and inflammation because of its anti-inflammatory properties.

    CBD Oil for Rheumatoid Arthritis

    Páleníček et al. (2017) explained that CBD oil affects brain activity, but it is not quite the same as the effect that tetrahydrocannabinol, the primary psychoactive component in marijuana, has. Instead, cannabidiol oil lessens the effects of pain and inflammation by interacting with the receptors known as CB1 and CB2.

    Additionally, CB2 is an essential component of the immune system. RA affects the immune system by causing damage to the tissue in the joints. It is possible that this relationship with the immune system could explain why cannabidiol oil is effective in treating RA symptoms.

    Moreover, Philpott et al.  (2017) reported that the anti-inflammatory effects of CBD slow down and prevent the progression of rheumatoid arthritis, which causes lasting damage to one’s joints over time. These outcomes may also have the effect of reducing the number of other RA symptoms that are associated with inflammation, such as fever and exhaustion.

    Cannabidiol Oil and Arthritis Pain Relief

    Osteoarthritis and rheumatoid arthritis are among the most common forms of the joint condition known as arthritis. Guilak et al. (2020) stated that osteoarthritis is a degenerative condition affecting the bones and the cartilage that lines the joints. This condition causes stiffness and pain and affects the knee, hip, and thumb.

    Rheumatoid arthritis is a form of autoimmune illness in which the body's immune system attacks a person's joints, causing inflammation in those joints. In most cases, it manifests in the hands and feet, causing the joints to become swollen, painful, and stiff.

    Moltke& Hindocha (2021) stated that the Arthritis Foundation showed that people with arthritis using cannabidiol report better sleeping, experiencing less pain, or having less anxiety. However, the study also claims that there have been no severe clinical studies in individuals with arthritis to validate this claim. As a result, the organization has persuaded the Food and Drug Administration to start regulating cannabidiol products and researching them. Learn more about is cbd oil good for arthritis?

    CBD and Chronic Pain

    Cannabinoids, like CBD, affect the body's receptors responsible for inflammation and pain. De Almeida & Devi (2020) stated cannabidiol (CBD) affects how these receptors respond to the signals they receive, which could potentially help reduce pain and inflammation.

    According to Tick et al.  (2018), cannabidiol may benefit patients suffering from chronic pain. However, most of the research on CBD's effectiveness in treating chronic pain has focused on nerve-related or neuropathic pain as its primary focus. Hill et al.  (2017) noted that cannabidiol helped with the chronic neuropathic pain experienced by humans.

    Argueta et al.  (2020) showed that   CBD alleviates chronic pain, increases sleep, and lowers inflammation. However, Rein (2020) noted that cannabidiol (CBD) might also have potential risks, including interactions with other medications and potentially hazardous components in unregulated commodities.

    Using CBD Oil

    CBD products are available in a wide variety of different forms and compositions. People determine how frequently they should use the product, how much they should use it, and how to apply it by following the instructions printed on the label and package of the product.

    Doses differ for each individual based on several parameters, including potency and body weight. According to medical professionals' recommendations, those new to using CBD should begin with the smallest possible dosage and gradually increase it if necessary.

    CBD can be administered in various ways, including orally, sublingually, inhaling, or topically. Oral administration includes consuming edibles or soft gels, while sublingual involves placing oil tincture under the tongue for absorption. Inhaling CBD is done by vaping the oil. This method is said to be the most effective, its effects are instant, and topical administration is applying CBD on the localized area, usually on a section of the skin.

    Since the FDA does not regulate cannabidiol products, users should research and buy high-quality goods. When choosing a CBD oil, ensure it comes from a reputable firm and has an exhaustive list of its components. Also, consult the primary care physician to determine the appropriate dosage. Begin with a small dosage and monitor how the body reacts. Gradually raise the dosage if you do not achieve the anticipated effects.

    Side Effects of Cannabidiol Oil

    McGuire et al. (2020) showed that the consumption of cannabidiol oil is not associated with fatal side effects. These are some of the effects:

    • Fatigue
    • Diarrhea
    • Alterations in one's appetite
    • Changes in weight

    However, Kocis& Vrana (2020) indicated that cannabidiol inhibits an enzyme called the cytochrome P450 complex when it interacts with medication. The presence of this enzyme improves the liver's ability to process toxins. As a result, the cannabidiol may enhance the likelihood of an increase in the liver's toxicity.

    Additionally, before using CBD, individuals should discuss it with their primary care provider. There is a possibility that it will interact negatively with some over-the-counter dietary modifications, aids, and drugs. CBD should not be taken alongside other medicines because of the possible interactions.


    It's important to complete your research before jumping on the bandwagon of using CBD for pain management. Cannabidiol, or CBD, can help patients with rheumatoid arthritis (RA) manage their pain and inflammation. Despite the minimal evidence is support this assertion. Major side effects are not often connected with the consumption of CBD but with other additives.

    Rheumatoid patients should discuss with their healthcare professionals to determine whether CBD is something they can use to manage this condition. However, CBD should not be used as a primary treatment for RA pain, and it is not a good idea to cease taking disease-modifying medicines for RA. Learn more about how to take cbd oil drops?


    Argueta, D. A., Ventura, C. M., Kiven, S., Sagi, V., & Gupta, K. (2020). A balanced approach for cannabidiol use in chronic pain. Frontiers in pharmacology, 11, 561.

    Chesney, E., Oliver, D., Green, A., Sovi, S., Wilson, J., Englund, A., ... & McGuire, P. (2020). Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials. Neuropsychopharmacology, 45(11), 1799-1806.

    de Almeida, D. L., & Devi, L. A. (2020). Diversity of molecular targets and signaling pathways for CBD. Pharmacology research & perspectives, 8(6), e00682.


    Ghasemi, S., Davoodi, P., Mashhadi Akbar Boojar, F., & Dashti, M. (2022). Efficacy of utilizing cannabidiol in reduction of inflammation and autoimmunity manifestation. Open Access Research Journal of Biology and Pharmacy, 4, 040-047.

    Hill, K. P., Palastro, M. D., Johnson, B., & Ditre, J. W. (2017). Cannabis and pain: a clinical review. Cannabis and cannabinoid research, 2(1), 96-104.

    McInnes, I. B., & Schett, G. (2017). Pathogenetic insights from the treatment of rheumatoid arthritis. The Lancet, 389(10086), 2328-2337.

    Hložek, T., Uttl, L., Kadeřábek, L., Balíková, M., Lhotková, E., Horsley, R. R., ... & Páleníček, T. (2017). Pharmacokinetic and behavioural profile of THC, CBD, and THC+ CBD combination after pulmonary, oral, and subcutaneous administration in rats and confirmation of conversion in vivo of CBD to THC. European Neuropsychopharmacology, 27(12), 1223-1237.

    Kocis, P. T., & Vrana, K. E. (2020). Delta-9-tetrahydrocannabinol and cannabidiol drug-drug interactions. Medical cannabis and cannabinoids, 3(1), 61-73.

    Moltke, J., & Hindocha, C. (2021). Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems. Journal of cannabis research, 3(1), 1-12.

    Philpott, H. T., O'Brien, M., & McDougall, J. J. (2017). Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain, 158(12), 2442.

    Rein, J. L. (2020). The nephrologist's guide to cannabis and cannabinoids. Current Opinion in Nephrology and Hypertension, 29(2), 248.

    Tick, H., Nielsen, A., Pelletier, K. R., Bonakdar, R., Simmons, S., Glick, R., ... & Zador, V. (2018). Evidence-based nonpharmacologic strategies for comprehensive pain care: the consortium pain task force white paper. Explore, 14(3), 177-211.

    Wu, C. L., Harasymowicz, N. S., Klimak, M. A., Collins, K. H., & Guilak, F. (2020). The role of macrophages in osteoarthritis and cartilage repair. Osteoarthritis and cartilage, 28(5), 544-554.

    Nicola Boulton
    Nicola Boulton

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