What Does CBG Do to Your Body?

Some people take drugs and other substances into their bodies without understanding the effects. A person can take CBG for positive results. Herein is about what CBG can do to a body, including; benefits, arguments against CBG, and combining CBG and CBD.

CBD is the most well-known cannabinoid. What about CBG? CBG is a' minor cannabinoid', but current scientific research says it has numerous health benefits due to its anti-inflammatory and antioxidant properties. Research is concerned with the therapeutic effects of CBG. Did you know that CBG was discovered in 1964? However, medical researchers have neglected the research on CBG, but currently, researchers have realized that CBG has anti-inflammatory properties. CBG is the next big thing in the market. This article will explore the benefits of CBG and how it works in the body. Follow for more.

CBG Action in the Endocannabinoid System

It is important to understand how CBG works in the body. The interaction between cannabis and the endocannabinoid system has been extensively researched. There is evidence that ECS comprises cannabinoid receptors, endogenous ligands, and enzymes. People are interested in the receptors. There are two receptors; CB1 and CB2. CBG bind to the two receptors. The role of the receptors in the endocannabinoid system is to mediate the action, or rather, they are responsible for the cannabinoid's psychotropic effect, such as modulating pain and inflammation.

Potential Benefits of CBG

CBG has several therapeutic potentials for the following conditions.

Huntington Disease

According to Valdeolivas et al. (2015), CBG has neuroprotective potential for treating Huntington's disease and other neurologic conditions. Note that Huntington's disease affects the brain; over time, the disease progresses and becomes a devastating illness. Patients experience mood swings, difficulty moving, difficulty concentrating, and other symptoms. The research has not yet come up with the best treatment since the disease is complicated. The study above also stated that the CBG's neuroprotective properties promote thought, memory, and thinking from deteriorating.

Inflammatory Bowel Disease

Kogan et al. (2012) discovered that CBG has anti-inflammatory properties for treating gastrointestinal diseases. IBD is a serious disease that may lead to complications such as bowel damage. The disease has no cure; it only requires lifelong management. However, 'cannabis cures cancer. The study above also stated that CBG's anti-inflammatory properties effectively reduce tumor growth.

Metabolic Syndrome

Metabolic syndrome is a serious condition that causes heart disease, blood pressure, abnormal cholesterol, and other illnesses. Millions of Americans suffer from this condition, associated with high health costs and higher mortality from cardiovascular disease. The current medication and intervention to treat this condition have not been widely accepted, and this indicates that there is a need for a combination of multiple drugs to combat the disease. CBG is a potential therapy for metabolic syndrome. Nachnani et al. (2021), CBG acts as an agonist therapy that reduces vasoconstriction, reduces neuroinflammation, and improves adipogenesis.

Antibacterial Agent

CBG is a long-forgotten cannabinoid but is the best against antibiotic-resistant strains. For example, Staphylococcus aureus bacteria are resistant to antibiotic drugs. According to Schofs et al.(2021), CBG has antibacterial activity and can destroy cells resistant to antibiotics.

Appetite Stimulant

According to Farrimond et al. (2012), CBG regulates feeding behavior without psychoactive side effects. The study above revealed that CBG works by interacting with ECB and non-ECB targets to control feeding. CBG has appetite-stimulating properties which combat eating disorders such as anorexia and appetite impairment.

Potential Treatment for Anxiety Disorders

Fear and anxiety are adaptive responses. However, excess fear and anxiety may worsen your mental and physical condition. Current treatments for fear and anxiety include tricyclic antidepressant drugs, anticonvulsants, and others. The medications do not effectively release stress; clinical research is essential for discovering new treatments. In recent years, scientific research has shown interest in finding the benefits of CBG in anxiety disorders. Current knowledge shows that CBG interacts with the central nervous system, reducing amygdala activation and protecting against psychotic symptoms, memory loss, and anxiety symptoms.

CBG in Glaucoma Patients

Living without eyesight can be frustrating. Glaucoma is an eye condition that can cause blindness. Malhotra et al. (2021) noted that CBG has therapeutic potential in treating symptoms associated with glaucoma. The study above also suggested that cannabinoids have anti-glaucoma agents that lower intraocular pressure. CBG binds into both CB1, and CB2 binds to modulate retina processes.

Potential Argument Against CBG

Everything has two sides. Having looked at CBG's therapeutic effects, there is a negative side. CBG has unintended side effects. The most potential side effect is on the cardiovascular. CBG is a potent agonist of Alpha-2 adrenoceptors. It causes cardiovascular effects such as bradycardia and hypertension. 

How CBG Interact With Medications

The liver is the primary site of drug metabolism. CBG may interfere with enzymes involved in the metabolism. CBG has been reported to interact with; 

• Blood thinner
• Blood pressure medication
• Corticosteroid
• Pain medication
• Anticancer medication 

Combing CBG and CBG

CBD is the most well-known compound in the cannabis plant. A person may wonder what would happen if CBG is mixed with  CBD. Combining the two compounds will give you the 'entourage effect'. They work best together, and the interaction will enhance the therapeutic effect. Combine the compounds if you want an amazing result. They bind to the receptors in different ways-meaning; although they have opposing effects on the body, they balance each other and offer a well-balanced experience. For example, CBD works on physical health conditions, while CBG is better suited for psychological issues. 

Conclusion

CBG is a non-psychoactive compound that helps treat many conditions due to its anti-inflammatory, antibacterial, and anticancer properties. As a minor cannabinoid, it has gained serious attention in recent years.  CBG use has grown more rapidly and gained popularity over the years. CBG must work in the endocannabinoid system through the help of the receptors to achieve the benefits.  CBG is medicine for different conditions, including glaucoma, Huntington's disease, dementia, diabetes, and more.  The CBG research is limited, even though the current knowledge reveals it has several benefits. Scientists are building their knowledge on CBG therapeutic effects. CBD and CBG differ in terms of their molecular structure and pharmacology. However, when combined, they produce the 'entourage effect' or, in other words, the benefits are multiplied. Don't worry why there is not much information about CBG. Scientists are always there to discover about the product. Be sure that CBG will be the next big thing in the future.

References

Farrimond, J. A., Whalley, B. J., & Williams, C. M. (2012). Cannabinol And Cannabidiol Exert Opposing Effects On Rat Feeding Patterns. Psychopharmacology, 223(1), 117-129.

Malhotra, P., Casari, I., & Falasca, M. (2021). Therapeutic Potential Of Cannabinoids In Combination Cancer Therapy. Advances In Biological Regulation, 79, 100774.

Kogan, N. M., Lavi, Y., Topping, L. M., Williams, R. O., Mccann, F. E., Yekhtin, Z., ... & Mechoulam, R. (2021). Novel CBG Derivatives Can Reduce Inflammation, Pain, And Obesity. Molecules, 26(18), 5601.

Nachnani, R., Raup-Konsavage, W. M., & Vrana, K. E. (2021). The Pharmacological Case For Cannabigerol. Journal Of Pharmacology And Experimental Therapeutics, 376(2), 204-212.

Schofs, L., Sparo, M. D., & Sanchez Bruni, S. F. (2021). The Antimicrobial Effect Behind Cannabis Sativa. Pharmacology Research & Perspectives, 9(2), E00761.

Valdeolivas, S., Navarrete, C., Cantarero, I., Bellido, M. L., Muñoz, E., & Sagredo, O. (2015). Neuroprotective Properties Of Cannabigerol In Huntington’s Disease: Studies In R6/2 Mice And 3-Nitropropionate-Lesioned Mice. Neurotherapeutics, 12(1), 185-199.